1-Chloro-9H-carbazole
[CAS 5599-70-2]

Identification

• Classification: Organic raw materials >> Heterocyclic compound >> Carbazoles
• Name: 1-Chloro-9H-carbazole
• Synonyms: 1-Chlorocarbazole
• Molecular Formula: C₁₂H₈ClN
• Molecular Weight: 201.65
• CAS Registry Number: 5599-70-2
• SMILES: C1=CC=C2C(=C1)C3=C(N2)C(=CC=C3)Cl

Properties

• Density: 1.4±0.1 g/cm³ Calc.^*
• Boiling point: 388.7±15.0 °C 760 mmHg (Calc.)^*
• Flash point: 221.0±6.0 °C (Calc.)^*
• Index of refraction: 1.767 (Calc.)^*

^* Calculated using Advanced Chemistry Development (ACD/Labs) Software.

Safety Data

• Hazard Symbols: GHS07 Warning
• Risk Statements: H302
• Safety Statements: P280-P305+P351+P338

chemBlink Chemical Story

1-Chloro-9H-carbazole is a chlorinated derivative of carbazole, the tricyclic aromatic heterocycle containing a nitrogen-bearing five-membered ring fused between two benzene rings. Carbazole chemistry extends from early coal-tar studies to modern functional materials and medicinal-chemistry scaffolds. Chlorine at the 1-position changes the electronic and steric environment and provides a possible site for later substitution or cross-coupling, while the 9H nitrogen remains available for N-substitution. These two directions make the compound useful for preparing more elaborate carbazole derivatives. Public exact-CAS sources do not establish one dominant commercial end use, so its story is best centered on heteroaromatic building-block chemistry rather than inferred biological activity.

Exact registry identity matters because free forms, salts, stereoisomers, hydrates, intermediates, and final products may have different CAS numbers even when names are closely related. Those distinctions can change molecular weight, solubility, crystallinity, analytical standards, and interpretation of published data. A reliable database therefore follows the exact substance rather than automatically transferring properties from a related form.

Functional groups provide a map of intended reactivity. Alcohols, amines, halides, esters, alkenes, and heteroaromatic rings offer different opportunities for bond formation, while the surrounding framework controls shape, electronics, and solubility. In multistep synthesis, a useful intermediate often succeeds because one position can be changed selectively while another remains available for a later operation.

Modern chemical development depends on characterization as well as synthesis. Identity, purity, stereochemistry, salt or water content, and process-related impurities may all require control. Well-characterized intermediates and reference materials remain important even when they never become final commercial products because reproducible chemistry depends on knowing exactly which substance is present.

A responsible Chemical Story distinguishes documented application from structural possibility. A familiar scaffold can suggest hypotheses, but resemblance alone does not establish a biological target, approved indication, or industrial adoption. When exact-CAS literature is limited, verified chemistry and clearly documented applications are more useful than speculation.

Practical behavior emerges from the complete molecular and material system. Structure, physical form, reaction conditions, manufacturing route, and surrounding environment can all affect performance. Connecting these details to a documented synthetic, industrial, analytical, or biological role is what turns a registry entry into a meaningful chemical story.

Exact registry identity matters because free forms, salts, stereoisomers, hydrates, intermediates, and final products may have different CAS numbers even when names are closely related. Those distinctions can change molecular weight, solubility, crystallinity, analytical standards, and interpretation of published data. A reliable database therefore follows the exact substance rather than automatically transferring properties from a related form.

Functional groups provide a map of intended reactivity. Alcohols, amines, halides, esters, alkenes, and heteroaromatic rings offer different opportunities for bond formation, while the surrounding framework controls shape, electronics, and solubility. In multistep synthesis, a useful intermediate often succeeds because one position can be changed selectively while another remains available for a later operation.

Modern chemical development depends on characterization as well as synthesis. Identity, purity, stereochemistry, salt or water content, and process-related impurities may all require control. Well-characterized intermediates and reference materials remain important even when they never become final commercial products because reproducible chemistry depends on knowing exactly which substance is present.

A responsible Chemical Story distinguishes documented application from structural possibility. A familiar scaffold can suggest hypotheses, but resemblance alone does not establish a biological target, approved indication, or industrial adoption. When exact-CAS literature is limited, verified chemistry and clearly documented applications are more useful than speculation.

References:
1. Specialist chemical catalogs. CAS 5599-70-2.
2. Reviews of carbazole chemistry in functional materials and medicinal chemistry.

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